原创力文档responsive electrical stimulation suppresses epileptic seizures in rats反应在大鼠电刺激抑制癫痫发作.pdfVIP
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responsive electrical stimulation suppresses epileptic seizures in rats反应在大鼠电刺激抑制癫痫发作
Responsive Electrical Stimulation Suppresses Epileptic
Seizures in Rats
1,2 3. 1. 4,5 1 1 3
Lei Wang , Heng Guo , Xiao Yu , Shouyan Wang , Canhua Xu , Feng Fu , Xiaorong Jing ,
3 1
Hua Zhang *, Xiuzhen Dong *
1 Faculty of Biomedical Engineering, the Fourth Military Medical University, Xi’an, China, 2 The 323rd Hospital of PLA, Xi’an, China, 3 Department of Neurosurgery, Tangdu
Hospital, the Fourth Military Medical University, Xi’an, China, 4 Hearing and Balance Centre, Institute of Sound and Vibration Research, Southampton, United Kingdom,
5 Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China
Abstract
Background: A responsive electrical stimulation pattern based on our recently developed novel seizure prediction method
was designed to suppress the penicillin-induced epileptic seizures.
Methodology: Seizures were induced by Penicillin injection at rat cortex. A responsive electrical stimulation system was
triggered prior to seizures predicted with phase synchronisation. Rats with induced seizures were stimulated by the
electrical pulses at a responsive or 1 Hz periodic pattern of an open system. The effectiveness of stimulation on seizures
suppression was assessed by measuring the average number and duration of seizures per hour.
Results: The prediction algorithm reliably identified seizures in real time and triggered the responsive stimulation. This type
of electrical stimulation dramatically suppressed seizure activity and the performance was better than the open stimulation
system with fewer and shorter seizures.
Conclusions: A responsive electrical stimulation system triggered by the phase synch
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