resting-state functional connectivity patterns predict chinese word reading competency静息状态的功能连通性模式预测中国文字阅读能力.pdfVIP

Resting-State Functional Connectivity Patterns Predict Chinese Word Reading Competency Xiaosha Wang, Zaizhu Han, Yong He, Li Liu, Yanchao Bi* State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China Abstract Resting-state functional connectivity (RSFC) offers a novel approach to reveal the temporal synchronization of functionally related brain regions. Recent studies have identified several RSFCs whose strength was associated with reading competence in alphabetic languages. In the present study, we examined the role of intrinsic functional relations for reading a non- alphabetic language – Chinese – by correlating RSFC maps of nine Chinese reading-related seed regions and reaction time in the single-character reading task. We found that Chinese reading efficiency was positively correlated with the connection between left inferior occipital gyrus and left superior parietal lobule, between right posterior fusiform gyrus and right superior parietal lobule, and between left inferior temporal gyrus and left inferior parietal lobule. These results could not be attributed to inter-individual differences arising from the peripheral processes of the reading task such as visual input detection and articulation. The observed RSFC-reading correlation relationships are discussed in the framework of Chinese character reading, including visuospatial analyses and semantic/phonological processes. Citation: Wang X, Han Z, He Y, Liu L, Bi Y (2012) Resting-State Functional Connectivity Patterns Predict Chinese Word Reading Competency. PLoS ONE 7(9): e44848. doi:10.1371/journal.pone.0044848 Editor: Olaf Sporns, Indiana University, United States of America Received May 10, 2012; Accepted August 7, 2012; Published September 24, 2012 Copyright: 2012 Wang et al. This is an open-access article d