原创力文档restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma恢复p38皮质类固醇敏感的有丝分裂原激活蛋白激酶抑制外周血单核细胞从严重的哮喘.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma恢复p38皮质类固醇敏感的有丝分裂原激活蛋白激酶抑制外周血单核细胞从严重的哮喘
Restoration of Corticosteroid Sensitivity by p38 Mitogen
Activated Protein Kinase Inhibition in Peripheral Blood
Mononuclear Cells from Severe Asthma
1 1,2 1 1,2 1,2
Nicolas Mercado , Amir Hakim , Yoshiki Kobayashi , Sally Meah , Omar S. Usmani , Kian
1,2 1 1
Fan Chung , Peter J. Barnes , Kazuhiro Ito *
1 Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom, 2 Biomedical Research Unit, Royal Brompton Hospital and
Imperial College, London, United Kingdom
Abstract
Background: Severe asthma accounts for a small number of asthmatics but represents a disproportionate cost to health
care systems. The underlying mechanism in severe asthma remains unknown but several mechanisms are likely to be
involved because of a very heterogeneous profile. We investigated the effects of a p38MAPK inhibitor in corticosteroid
sensitivity in peripheral blood mononuclear cells (PBMCs) from severe asthmatics and the profile of its responders.
Methodology/Principal Findings: Corticosteroid sensitivity was determined by measuring dexamethasone inhibition of
CD3/28 and TNF-a induced IL-8 production in PBMCs by using ELISA. PBMCs from severe asthmatics were relatively less
sensitive to dexamethasone (Dex) as compared to those of non-severe asthmatics and healthy volunteers. The IC50 values of
Dex negatively correlated with decreased glucocorticoid receptor (GR) nuclear translocation assessed using immunocy-
tochemistry (r = 20.65; p,0.0005) and with decreased FEV1 (% predicted) (r = 0.6; p,0.0005). A p38a/ b inhibitor (SB203580)
restored Dex-sensit
您可能关注的文档
- relative importance of modularity and other morphological attributes on different types of lithic point weapons assessing functional variations模块化和其他形态属性的相对重要性在不同类型的岩屑点武器评估功能的变化.pdf
- relative quantification of protein-protein interactions using a dual luciferase reporter pull-down assay system蛋白质相互作用的相对量化使用双荧光素酶记者拉试验系统.pdf
- relativity theory and time perception single or multiple clocks相对论和时间知觉单个或多个时钟.pdf
- relative roles of the cellular and humoral responses in the drosophila host defense against three gram-positive bacterial infections相对作用的细胞和体液反应果蝇宿主防御三个革兰氏阳性细菌感染.pdf
- release from cross-orientation suppression facilitates 3d shape perception释放cross-orientation抑制促进三维形状知觉.pdf
- release of sicam-1 in oocytes and in vitro fertilized human embryos释放sicam-1在人类卵母细胞和体外受精胚胎.pdf
- relative number and distribution of murine hypothalamic proopiomelanocortin neurons innervating distinct target sites小鼠下丘脑proopiomelanocortin神经元的相对数量和分布支配不同的目标网站.pdf
- release of ku and mrn from dna ends by mre11 nuclease activity and ctp1 is required for homologous recombination repair of double-strand breaks从dna末端释放ku和mrn mre11核酸酶活性和ctp1同源重组修复需要的双链断裂.pdf
- relaxin signals through a rxfp1-perk-nnos-no-cgmp-dependent pathway to up-regulate matrix metalloproteinases the additional involvement of inos松弛素的信号通过rxfp1-perk-nnos-no-cgmp-dependent通路调控的基质金属蛋白酶伊诺的额外的参与.pdf
- relationship between immediate post-operative appearance and 6-week operative outcome in trichiasis surgery直接关系持续6周术后外观和手术结果倒睫手术.pdf
- result publication of chinese trials in world health organization primary registries世界卫生组织出版的中国试验结果主要注册.pdf
- responses of human endothelial cells to pathogenic and non-pathogenic leptospira species反应人类内皮细胞的致病性和非致病性钩端螺旋体的物种.pdf
- resurrection of a bull by cloning from organs frozen without cryoprotectant in a ？80°c freezer for a decade复活一头公牛的克隆器官没有冷冻保护剂在冻结 80°c冷冻了十年.pdf
- restriction of hiv-1 replication in monocytes is abolished by vpx of sivsmmpbj限制hiv - 1复制在单核细胞由vpx sivsmmpbj的废除.pdf
- results of antiretroviral treatment interruption and intensification in advanced multi-drug resistant hiv infection from the optima trial抗逆转录病毒治疗的中断和加强在先进耐多药hiv感染的最适条件试验.pdf
- rest-mediated regulation of extracellular matrix is crucial for neural developmentrest-mediated调节细胞外基质对神经发育是至关重要的.pdf
- resurrection of dna function in vivo from an extinct genome复活基因组dna的函数体内的灭绝.pdf
- resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against aβ and aβ-metal complexes toxicity白藜芦醇作用不是通过anti-aggregative途径但主要是通过清除属性与aβaβ-metal复合物毒性.pdf
- results of genome-wide analyses on neurodevelopmental phenotypes at four-year follow-up following cardiac surgery in infancy全基因组分析的结果在4年随访心脏手术后神经发育表型在婴儿期.pdf
- resveratrol and black tea polyphenol combination synergistically suppress mouse skin tumors growth by inhibition of activated mapks and p53白藜芦醇和红茶多酚组合协同抑制小鼠皮肤肿瘤的生长激活mapks和p53的抑制.pdf
文档评论（0）