原创力文档resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against aβ and aβ-metal complexes toxicity白藜芦醇作用不是通过anti-aggregative途径但主要是通过清除属性与aβaβ-metal复合物毒性.pdfVIP
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resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against aβ and aβ-metal complexes toxicity白藜芦醇作用不是通过anti-aggregative途径但主要是通过清除属性与aβaβ-metal复合物毒性
Resveratrol Acts Not through Anti-Aggregative Pathways
but Mainly via Its Scavenging Properties against Ab and
Ab-Metal Complexes Toxicity
Alberto Granzotto, Paolo Zatta*
Centro Nazionale delle Ricerche, Istituto Tecnologie Biomediche (CNR-ITB), Metalloproteins Unit, Department of Biology, University of Padova, Padova, Italy
Abstract
It has been recently suggested that resveratrol can be effective in slowing down Alzheimer’s disease (AD) development. As
reported in many biochemical studies, resveratrol seems to exert its neuro-protective role through inhibition of b-amyloid
aggregation (Ab), by scavenging oxidants and exerting anti-inflammatory activities. In this paper, we demonstrate that
resveratrol is cytoprotective in human neuroblastoma cells exposed to Ab and or to Ab-metal complex. Our findings
suggest that resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties.
Citation: Granzotto A, Zatta P (2011) Resveratrol Acts Not through Anti-Aggregative Pathways but Mainly via Its Scavenging Properties against Ab and Ab-Metal
Complexes Toxicity. PLoS ONE 6(6): e21565. doi:10.1371/journal.pone.0021565
Editor: Peter Csermely, Semmelweis University, Hungary
Received April 1, 2011; Accepted June 2, 2011; Published June 27, 2011
Copyright: 2011 Granzotto, Zatta. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This work was supported by PRIN 2007. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the
manuscript.
Competing Interests: The authors have declared that no competing interests exist.
* E-mail: zatta@bio.unipd.it
Introduction
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