resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure白藜芦醇改善生存、血流动力学和能量在高血压导致心力衰竭大鼠模型.pdfVIP

Resveratrol Improves Survival, Hemodynamics and Energetics in a Rat Model of Hypertension Leading to Heart Failure ´ 1,2 1,2 ´ ˆ 1,2 1,2 1,2 Stephanie Rimbaud , Matthieu Ruiz , Jerome Piquereau , Philippe Mateo , Dominique Fortin , 1,2 1,2 ´ 1,2 Vladimir Veksler , Anne Garnier , Renee Ventura-Clapier * ˆ ˆ ˆ 1 UMR-S 769 Inserm, Univ Paris-Sud Chatenay-Malabry, Chatenay-Malabry, France, 2 Univ Paris-Sud, IFR 141, Chatenay-Malabry, France Abstract Heart failure (HF) is characterized by contractile dysfunction associated with altered energy metabolism. This study was aimed at determining whether resveratrol, a polyphenol known to activate energy metabolism, could be beneficial as a metabolic therapy of HF. Survival, ventricular and vascular function as well as cardiac and skeletal muscle energy metabolism were assessed in a hypertensive model of HF, the Dahl salt-sensitive rat fed with a high-salt diet (HS-NT). Resveratrol (18 mg/kg/day; HS-RSV) was given for 8 weeks after hypertension and cardiac hypertrophy were established (which occurred 3 weeks after salt addition). Resveratrol treatment improved survival (64% in HS-RSV versus 15% in HS-NT, p,0.001), and prevented the 25% reduction in body weight in HS-NT (P,0.001). Moreover, RSV counteracted the development of cardiac dysfunction (fractional shortening 234%