原创力文档resveratrol induces growth arrest and apoptosis through activation of foxo transcription factors in prostate cancer cells白藜芦醇通过激活细胞凋亡增长逮捕和foxo转录因子在前列腺癌细胞.pdfVIP
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resveratrol induces growth arrest and apoptosis through activation of foxo transcription factors in prostate cancer cells白藜芦醇通过激活细胞凋亡增长逮捕和foxo转录因子在前列腺癌细胞
Resveratrol Induces Growth Arrest and Apoptosis
through Activation of FOXO Transcription Factors in
Prostate Cancer Cells
1 2 3 4 5
Qinghe Chen , Suthakar Ganapathy , Karan P. Singh , Sharmila Shankar , Rakesh K. Srivastava *
1Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America, 2 Division of Radiation Biology,
Department of Radiation Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, 3 Department of
Biostatistics, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas, United States of America, 4 Department of Pathology and Laboratory
Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, Kansas, United States of America, 5 Department of Pharmacology,
Toxicology and Therapeutics, and Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
Abstract
Background: Resveratrol, a naturally occurring phytopolyphenol compound, has attracted extensive interest in recent years
because of its diverse pharmacological characteristics. Although resveratrol possesses chemopreventive properties against
several cancers, the molecular mechanisms by which it inhibits cell growth and induces apoptosis have not been clearly
understood. The present study was carried out to examine whether PI3K/AKT/FOXO pathway mediates the biological effects
of resveratrol.
Methodology/Principal Findings: Resveratrol inhibited the phosphorylation of PI3K, AKT and mTOR. Resveratrol, PI3K
inhibitors (LY294002 and Wortmannin) and AKT
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