原创力文档retinitis pigmentosa reduces the risk of proliferative diabetic retinopathy a nationwide population-based cohort study色素性视网膜炎可以减少增生性糖尿病性视网膜病变的风险一个全国性的以人群为基础的队列研究.pdfVIP
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retinitis pigmentosa reduces the risk of proliferative diabetic retinopathy a nationwide population-based cohort study色素性视网膜炎可以减少增生性糖尿病性视网膜病变的风险一个全国性的以人群为基础的队列研究
Retinitis Pigmentosa Reduces the Risk of Proliferative
Diabetic Retinopathy: A Nationwide Population-Based
Cohort Study
1,2 3,4 5 2 5,6 2,3
Yuh-Fang Chen , Hsin-Yi Chen , Che-Chen Lin , Muh-Shy Chen , Pei-Chun Chen , I-Jong Wang *
1 Department of Ophthalmology, New Taipei City Hospital, New Taipei City, Taiwan, 2 Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan,
3 Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, 4 Department of Ophthalmology, China Medical University Hospital,
Taichung, Taiwan, 5 Management Office for Health Data, China Medical University and Hospital, Taichung, Taiwan, 6 Graduate Institute of Epidemiology and Preventive
Medicine, National Taiwan University College of Public Health, Taipei, Taiwan
Abstract
Purpose: To study the association between retinitis pigmentosa (RP) and the progression of diabetic retinopathy (DR).
Methods: Using the Longitudinal Health Insurance Database 2000 of Taiwan, we identified individuals with an initial
diagnosis for RP during the period of 1997–2008. A non-RP comparison group, 10-fold frequency matched by sex, age, index
year and the year of diabetes diagnosed, were randomly selected from the same database. The occurrence of DR was
observed for all subjects until the end of 2009. The Kaplan-Meier curves were used to illustrate the cumulative probability of
developing DR for the RP group and comparison groups. The hazard ratio (HR) of DR for the RP group relative to the
comparison group was estimated using Cox proportional hazards model after adjusting for potential confounders.
Results: The Kaplan-Mei
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