原创力文档restoration of podocyte structure and improvement of chronic renal disease in transgenic mice overexpressing renin恢复足突细胞结构和改善慢性肾疾病的转基因老鼠overexpressing肾素.pdfVIP
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restoration of podocyte structure and improvement of chronic renal disease in transgenic mice overexpressing renin恢复足突细胞结构和改善慢性肾疾病的转基因老鼠overexpressing肾素
Restoration of Podocyte Structure and Improvement of
Chronic Renal Disease in Transgenic Mice
Overexpressing Renin
´ 1 2 3 4 1,5,6
Anne-Cecile Huby , Maria-Pia Rastaldi , Kathleen Caron , Oliver Smithies , Jean-Claude Dussaule ,
Christos Chatziantoniou1,5*
1 INSERM UMR 702, Paris, France, 2 Fondazione IRCCS Ospedale Maggiore Policlinico Fondazione D’Amico per la Ricerca sulle Malattie Renali, Milano, Italy,
3 Department of Molecular and Cell Physiology, University of North Carolina, Chapel Hill, North Carolina, United States of America, 4 Department of Pathology and
´
Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America, 5 Universite Pierre et Marie Curie-Paris VI, UMR S 702, Paris, France,
ˆ
6 AP-HP, Hopital St-Antoine, Department of Physiology, Paris, France
Abstract
Background: Proteinuria is a major marker of the decline of renal function and an important risk factor of coronary heart
disease. Elevated proteinuria is associated to the disruption of slit-diaphragm and loss of podocyte foot processes, structural
alterations that are considered irreversible. The objective of the present study was to investigate whether proteinuria can be
reversed and to identify the structural modifications and the gene/protein regulation associated to this reversal.
Methodology/Principal Findings: We used a novel transgenic strain of mouse (RenTg) that overexpresses renin at a constant
high level. At the age of 12-month, RenTg mice showed established lesions typical of chronic renal
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