restricted genetic diversity of hiv-1 subtype c envelope glycoprotein from perinatally infected zambian infants限制遗传多样性位围产期感染hiv - 1 c亚型包膜糖蛋白的赞比亚婴儿.pdfVIP

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restricted genetic diversity of hiv-1 subtype c envelope glycoprotein from perinatally infected zambian infants限制遗传多样性位围产期感染hiv - 1 c亚型包膜糖蛋白的赞比亚婴儿.pdf

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restricted genetic diversity of hiv-1 subtype c envelope glycoprotein from perinatally infected zambian infants限制遗传多样性位围产期感染hiv - 1 c亚型包膜糖蛋白的赞比亚婴儿

Restricted Genetic Diversity of HIV-1 Subtype C Envelope Glycoprotein from Perinatally Infected Zambian Infants 1,2. 1,2. 1,2 1,2 3 Hong Zhang , Damien C. Tully , Federico G. Hoffmann , Jun He , Chipepo Kankasa , Charles Wood1,2* 1 Nebraska Center for Virology, University of Nebraska, Lincoln, Nebraska, United States of America, 2 School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, United States of America, 3 Department of Pediatrics, University Teaching Hospital, Lusaka, Zambia Abstract Background: Mother-to-child transmission of HIV-1 remains a significant problem in the resource-constrained settings where anti-retroviral therapy is still not widely available. Understanding the earliest events during HIV-1 transmission and characterizing the newly transmitted or founder virus is central to intervention efforts. In this study, we analyzed the viral env quasispecies of six mother-infant transmission pairs (MIPs) and characterized the genetic features of envelope glycoprotein that could influence HIV-1 subtype C perinatal transmission. Methodology and Findings: The V1-V5 region of env was amplified from 6 MIPs baseline samples and 334 DNA sequences in total were analyzed. A comparison of the viral population derived from the mother and infant revealed a severe genetic bottleneck occurring during perinatal transmission, which was characterized by low sequence diversity in the infant. Phylogenetic analysis indicates that most likely in all our infant subjects a single founder virus was responsible for establishing infection. Furthermore, the newly transmitted viruses from the infan