relationships between gene expression and brain wiring in the adult rodent brain基因表达之间的关系和大脑连接在成年人的啮齿动物的大脑.pdfVIP

Relationships between Gene Expression and Brain Wiring in the Adult Rodent Brain Leon French1,2, Paul Pavlidis2,3* 1 Bioinformatics Graduate Program, University of British Columbia, Vancouver, British Columbia, Canada, 2 Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia, Canada, 3 Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada Abstract We studied the global relationship between gene expression and neuroanatomical connectivity in the adult rodent brain. We utilized a large data set of the rat brain ‘‘connectome’’ from the Brain Architecture Management System (942 brain regions and over 5000 connections) and used statistical approaches to relate the data to the gene expression signatures of 17,530 genes in 142 anatomical regions from the Allen Brain Atlas. Our analysis shows that adult gene expression signatures have a statistically significant relationship to connectivity. In particular, brain regions that have similar expression profiles tend to have similar connectivity profiles, and this effect is not entirely attributable to spatial correlations. In addition, brain regions which are connected have more similar expression patterns. Using a simple optimization approach, we identified a set of genes most correlated with neuroanatomical connectivity, and find that this set is enriched for genes involved in neuronal development and axon guidance. A number of the genes have been implicated in neurodevelopmental disorders such as autistic spectrum disorder. Our results have the potential to shed light on the role of gene expression patterns in influencing neuronal activity and connectivity, with potential applications to our understanding of brain disorders. Supplementary data are available at http://www.chibi.ubc.ca/AB