原创力文档regular patterns in cerebellar purkinje cell simple spike trains小脑浦肯野细胞的有规律性的模式简单的高峰列车.pdfVIP
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regular patterns in cerebellar purkinje cell simple spike trains小脑浦肯野细胞的有规律性的模式简单的高峰列车
Regular Patterns in Cerebellar Purkinje Cell Simple Spike
Trains
1 2 2 2 3 1,4
Soon-Lim Shin , Freek E. Hoebeek , Martijn Schonewille , Chris I. De Zeeuw , Ad Aertsen , Erik De Schutter *
1Theoretical Neurobiology, University of Antwerp, Antwerp, Belgium, 2 Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands,
3 Neurobiology and Biophysics, Faculty of Biology and Bernstein Center for Computational Neuroscience, Albert-Ludwigs-University, Freiburg,
Germany, 4 Computational Neuroscience Unit, Okinawa Institute of Science and Technology, Okinawa, Japan
Background. Cerebellar Purkinje cells (PC) in vivo are commonly reported to generate irregular spike trains, documented by
high coefficients of variation of interspike-intervals (ISI). In strong contrast, they fire very regularly in the in vitro slice
preparation. We studied the nature of this difference in firing properties by focusing on short-term variability and its
dependence on behavioral state. Methodology/Principal Findings. Using an analysis based on CV2 values, we could isolate
precise regular spiking patterns, lasting up to hundreds of milliseconds, in PC simple spike trains recorded in both
anesthetized and awake rodents. Regular spike patterns, defined by low variability of successive ISIs, comprised over half of
the spikes, showed a wide range of mean ISIs, and were affected by behavioral state and tactile stimulation. Interestingly,
regular patterns often coincided in nearby Purkinje cells without precise synchronization of individual spikes. Regular patterns
exclusively appeared during the up state of the PC membrane potential, while single ISIs occurred both during up and down
states. Poss
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