recent emergence of staphylococcus aureus clonal complex 398 in human blood cultures最近出现金黄色葡萄球菌398年克隆复杂的人类血液的文化.pdfVIP

Recent Emergence of Staphylococcus aureus Clonal Complex 398 in Human Blood Cultures 1,2 1,3 4 5,6 4 Erwin Verkade *, Anneke M. C. Bergmans , Andries E. Budding , Alex van Belkum , Paul Savelkoul , Anton G. Buiting2, Jan Kluytmans1,2,4 1 Laboratory for Microbiology and Infection Control, Amphia Hospital, Breda, The Netherlands, 2 Laboratory for Medical Microbiology and Immunology, St. Elisabeth Hospital, Tilburg, The Netherlands, 3 Laboratory for Microbiology, Franciscus Hospital, Roosendaal, The Netherlands, 4 Department of Medical Microbiology, VU University medical centre, Amsterdam, The Netherlands, 5 Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands, ´ 6 bioMerieux, Microbiology R and D, La Balme Les Grottes, France Abstract Background: Recently, a clone of MRSA with clonal complex 398 (CC398) has emerged that is related to an extensive reservoir in animals, especially pigs and veal calves. It has been reported previously that methicillin-susceptible variants of CC398 circulate among humans at low frequency, and these have been isolated in a few cases of bloodstream infections (BSI). The purpose of this study was to determine the prevalence of S. aureus CC398 in blood cultures taken from patients in a geographic area with a high density of pigs. Methodology/Principal Findings: In total, 612 consecutive episodes of S. aureus BSI diagnosed before and during the emergence of CC398 were included. Three strains (2 MSSA and 1 MRSA) that were isolated from bacteremic patients between 2010–2011 were positive in a CC398 specific PCR.