quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting vegfr- 2 regulated aktmtorp70s6k signaling pathways槲皮素抑制血管生成调节人类前列腺癌肿瘤的生长通过瞄准vegfr - 2规范aktmtorp70s6k信号通路.pdfVIP

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quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting vegfr- 2 regulated aktmtorp70s6k signaling pathways槲皮素抑制血管生成调节人类前列腺癌肿瘤的生长通过瞄准vegfr - 2规范aktmtorp70s6k信号通路.pdf

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quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting vegfr- 2 regulated aktmtorp70s6k signaling pathways槲皮素抑制血管生成调节人类前列腺癌肿瘤的生长通过瞄准vegfr - 2规范aktmtorp70s6k信号通路

Quercetin Inhibits Angiogenesis Mediated Human Prostate Tumor Growth by Targeting VEGFR- 2 Regulated AKT/mTOR/P70S6K Signaling Pathways 1 1 1 1 1 1 Poyil Pratheeshkumar , Amit Budhraja , Young-Ok Son , Xin Wang , Zhuo Zhang , Songze Ding , 1 1 1 2 2 2 1 Lei Wang , Andrew Hitron , Jeong-Chae Lee , Mei Xu , Gang Chen , Jia Luo , Xianglin Shi * 1 Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America, 2 Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America Abstract Angiogenesis is a crucial step in the growth and metastasis of cancers, since it enables the growing tumor to receive oxygen and nutrients. Cancer prevention using natural products has become an integral part of cancer control. We studied the antiangiogenic activity of quercetin using ex vivo, in vivo and in vitro models. Rat aortic ring assay showed that quercetin at non-toxic concentrations significantly inhibited microvessel sprouting and exhibited a significant inhibition in the proliferation, migration, invasion and tube formation of endothelial cells, which are key events in the process of angiogenesis. Most importantly, quercetin treatment inhibited ex vivo angiogenesis as revealed by chicken egg chorioallantoic membrane assay (CAM) and matrigel plug assay. Western blot analysis showed that quercetin suppressed VEGF induced phosphorylation of VEGF receptor 2 and their downstream protein kinases AKT, mTOR, and ribosomal protein