quinolone resistance in absence of selective pressure the experience of a very remote community in the amazon forest喹诺酮耐药在没有选择压力的经历一个非常偏远的社区在亚马逊森林.pdfVIP

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quinolone resistance in absence of selective pressure the experience of a very remote community in the amazon forest喹诺酮耐药在没有选择压力的经历一个非常偏远的社区在亚马逊森林.pdf

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quinolone resistance in absence of selective pressure the experience of a very remote community in the amazon forest喹诺酮耐药在没有选择压力的经历一个非常偏远的社区在亚马逊森林

Quinolone Resistance in Absence of Selective Pressure: The Experience of a Very Remote Community in the Amazon Forest 1. 2,3. 1 4 2 Lucia Pallecchi , Alessandro Bartoloni , Eleonora Riccobono , Connie Fernandez , Antonia Mantella , 2 2 2 3 4 Donata Magnelli , Dario Mannini , Marianne Strohmeyer , Filippo Bartalesi , Hugo Rodriguez , Eduardo Gotuzzo5, Gian Maria Rossolini1,6* ` 1 Dipartimento di Biotecnologie, Sezione di Microbiologia, Universita di Siena, Siena, Italy, 2 Dipartimento Area Critica Medico Chirurgica, Clinica Malattie Infettive, ` Universita di Firenze, Florence, Italy, 3 Malattie Infettive e Tropicali, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy, 4 Hospital Apoyo Yurimaguas, Yurimaguas, Peru, 5 Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru, 6 Dipartimento di Emergenza, Urgenza e dei Servizi Diagnostici, U. O. Microbiologia e Virologia, Azienda Ospedaliera-Universitaria Senese, Siena, Italy Abstract Background: Quinolones are potent broad-spectrum bactericidal agents increasingly employed also in resource-limited countries. Resistance to quinolones is an increasing problem, known to be strongly associated with quinolone exposure. We report on the emergence of quinolone resistance in a very remote community in the Amazon forest, where quinolones have never been used and quinolone resistance was absent in 2002. Methods: The community exhibited a considerable level of geographical isolation, limit