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rabies diagnosis for developing countries为发展中国家狂犬病诊断
Rabies Diagnosis for Developing Countries
¨ 1 ¨ 2 3 2 4
Salome Durr , Service Naıssengar , Rolande Mindekem , Colette Diguimbye , Michael Niezgoda , Ivan
Kuzmin4, Charles E. Rupprecht4, Jakob Zinsstag 1*
´ ´ ´ ´
1 Swiss Tropical Institute, Basel, Switzerland, 2 Laboratoire de Recherches Veterinaires et Zootechniques de Farcha, N’Djamena, Tchad, 3 Centre de Support en Sante
´
International, N’Djamena, Tchad, 4 Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
Abstract
Background: Canine rabies is a neglected disease causing 55,000 human deaths worldwide per year, and 99% of all cases
´
are transmitted by dog bites. In N’Djamena, the capital of Chad, rabies is endemic with an incidence of 1.71/1,000 dogs (95%
C.I. 1.45–1.98). The gold standard of rabies diagnosis is the direct immunofluorescent antibody (DFA) test, requiring a
fluorescent microscope. The Centers for Disease Control and Prevention (CDC, Atlanta, United States of America) developed
a histochemical test using low-cost light microscopy, the direct rapid immunohistochemical test (dRIT).
´
Methodology/Principal Findings: We evaluated the dRIT in the Chadian National
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