rabies exposures, post-exposure prophylaxis and deaths in a region of endemic canine rabies狂犬病暴露,接触后预防犬类狂犬病流行地区和死亡.pdfVIP

Rabies Exposures, Post-Exposure Prophylaxis and Deaths in a Region of Endemic Canine Rabies 1,2 2 3{ 4 5 Katie Hampson *, Andy Dobson , Magai Kaare , Jonathan Dushoff , Matthias Magoto , Emmanuel Sindoya5, Sarah Cleaveland6 1 Department of Animal and Plant Sciences, University of Sheffield, Western Bank, Sheffield, United Kingdom, 2 Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America, 3 Centre for Infectious Diseases, School of Biological Sciences, University of Edinburgh, King’s Buildings, Ashworth Laboratories, Edinburgh, Midlothian, United Kingdom, 4 Department of Biology, McMaster University, Hamilton, Ontario, Canada, 5 Minstry of Water and Livestock Development, Serengeti District Livestock Office, Mugumu, Tanzania, 6 Division of Infection and Immunity, The Roslin Institute/Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, Midlothian, United Kingdom Abstract Background: Thousands of human deaths from rabies occur annually despite the availability of effective vaccines following exposure, and for disease control in the animal reservoir. Our aim was to assess risk factors associated with exposure and to determine why human deaths from endemic canine rabies still occur. Methods and Findings: Contact tracing was used to gather data on rabies exposures, post-exposure prophylaxis (PEP) delivered and deaths in two rural districts in northwestern Tanzania from 2002 to 2006. Data on risk factors and the propensity to seek and complete courses of PEP was collected using questionnaires. Exposures varied from 6–141/100,000 per year. Risk of exposu