rabies post-exposure prophylaxis in the philippines health status of patients having received purified equine f(ab)2 fragment rabies immunoglobulin (favirab)狂犬病暴露后预防在菲律宾健康状况的患者获得纯化马f(ab)2片段狂犬病免疫球蛋白(favirab).pdfVIP

Rabies Post-Exposure Prophylaxis in the Philippines: Health Status of Patients Having Received Purified Equine F(ab’)2 Fragment Rabies Immunoglobulin (Favirab) 1 2 2 3 1 Beatriz P. Quiambao , Hazel Z. DyTioco , Ruby M. Dizon , Marilyn E. Crisostomo , Thelma M. Laot , Dirk E. Teuwen4* 1 Research Institute for Tropical Medicine, Alabang, Manila, Philippines, 2 Sanofi Pasteur, Manila, Philippines, 3 College of Public Health, University of the Philippines, Quezon City, Manila, Philippines, 4 Sanofi Pasteur, Lyon, France Abstract Background: Recommended treatment for severe rabies exposure in unvaccinated individuals includes wound cleaning, administration of rabies immunoglobulins (RIG), and rabies vaccination. We conducted a survey of rabies treatment outcomes in the Philippines. Methods: This was a case series involving 7,660 patients (4 months to 98 years of age) given purified equine RIG (pERIG) at the Research Institute for Tropical Medicine (Muntinlupa, Philippines) from July 2003 to August 2004 following Category II or III exposures. Data on local and systemic adverse reactions (AR) within 28 days and biting animal status were recorded; outcome data were obtained by telephone or home visit 6–29 months post-exposure. Results: Follow-up data were collected for 6,464 patients. Of 151 patients with laboratory-confirmed rabies exposure, 143 were in good health 6–48 months later, seven could not be contacted, and one 4-year-old girl died. Of 16 deaths in total, 14 were unrelated to rabies exposure or treatment. Two deaths were considered PEP failures: the 4-year old girl, who had multiple deep lacerated wounds from a rabid dog of the nape, neck, and