原创力文档quercetin suppresses drug-resistant spheres via the p38 mapk–hsp27 apoptotic pathway in oral cancer cells槲皮素抑制耐药领域通过p38 mapk-hsp27凋亡通路在口腔癌细胞.pdfVIP
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quercetin suppresses drug-resistant spheres via the p38 mapk–hsp27 apoptotic pathway in oral cancer cells槲皮素抑制耐药领域通过p38 mapk-hsp27凋亡通路在口腔癌细胞
Quercetin Suppresses Drug-Resistant Spheres via the
p38 MAPK–Hsp27 Apoptotic Pathway in Oral Cancer
Cells
1 2 . 3 4 4 4
Su-Feng Chen , Shin Nieh * , Shu-Wen Jao , Chia-Lin Liu , Chien-Hua Wu , Yun-Ching Chang , Chin-
Yuh Yang5, Yaoh-Shiang Lin6,7*.
1 Department of Dental Hygiene, China Medical University, Taichung, Taiwan, 2 Department of Pathology, Tri-Service General Hospital National Defense Medical Center,
Taipei, Taiwan, 3 Division of Colon and Rectal Surgery, Tri-Service General Hospital National Defense Medical Center, Taipei, Taiwan, 4 Graduate Institute of Life Sciences,
National Defense Medical Center, Taipei, Taiwan, 5 Department of Dentistry, Shuang Ho Hospital Taipei Medical University, Taipei, Taiwan, 6 Department of
Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital National Defense Medical Center, Taipei, Taiwan, 7 Department of Otolaryngology-Head and Neck
Surgery, Chung Shan Medical University, Taichung, Taiwan
Abstract
Background: Treatment failure in oral squamous cell carcinoma (OSCC) leading to local recurrence(s) and metastases is
mainly due to drug resistance. Cancer stem cells (CSCs) are thought be responsible for the development of drug resistance.
However, the correlations between CSCs, drug resistance, and new strategy against drug resistance in OSCC remain elusive.
Methods: A drug-resistant sphere (DRSP) model was generated by using a nonadhesive culture system to induce drug-
resistant cells from SCC25 oral cancer cells. A comparative analysis was performed between the parent control cells and
DRSPs with a related treatment strategy focusing on the expression of epithelial–mesenchymal transition (EMT)-associated
markers, drug-resistance-related genes, and CSC properties in
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