原创力文档recent hiv-1 infection identification of individuals with high viral load setpoint in a voluntary counselling and testing centre in rural mozambique最近的hiv - 1感染与高病毒载量定位点识别个人自愿咨询和检测中心在莫桑比克农村.pdfVIP
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recent hiv-1 infection identification of individuals with high viral load setpoint in a voluntary counselling and testing centre in rural mozambique最近的hiv - 1感染与高病毒载量定位点识别个人自愿咨询和检测中心在莫桑比克农村
Recent HIV-1 Infection: Identification of Individuals with
High Viral Load Setpoint in a Voluntary Counselling and
Testing Centre in Rural Mozambique
1 2,3 ´ 2 ˜ 1 2 1
Celia Serna-Bolea *, Nilsa de Deus , Sozinho Acacio , Jose Munoz , Delino Nhalungo , Emilio Letang ,
1,2 1
Pedro Alonso , Denise Naniche *
´
1 Barcelona Centre for International Health Research (CRESIB, Hospital Clınic-Universtitat de Barcelona), Barcelona, Spain, 2 Manhic¸a Health Research Centre (CISM),
Manhic¸a, Mozambique, 3 National Institute of Health, Maputo, Mozambique
Abstract
Background: Identification of recent HIV-infections is important for describing the HIV epidemic and compiling HIV-RNA-
setpoint data for future HIV intervention trials. We conducted a study to characterize recent infections, and HIV-RNA-
setpoint within the adult population presenting at a voluntary counselling and testing centre (VCT) in southern
Mozambique.
Methods: All adults attending the Manhic¸a District-Hospital VCT between April and October 2009 were recruited if they had
at least one positive rapid HIV-serology test. Patients were screened for recent HIV-1 infection by BED-CEIA HIV-incidence
test. Clinical examination, assessment of HIV-RNA and CD4 cell counts were performed at enrollment, 4 and 10 months.
Results: Of the 492 participants included in this study, the prevalence of recent infections as defined by BED-CEIA test, CD4
counts .200 cells/ml and HIV-RNA .400 copies/mL, was 11.58% (57/492; 95% CI 8.89–14.74). Due to heterogeneity in HIV-
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