recent developments in yeast aging最近的事态发展在酵母老化.pdfVIP

Review Recent Developments in Yeast Aging Matt Kaeberlein*, Christopher R. Burtner, Brian K. Kennedy* ABSTRACT information regulator 2 (Sir2) family of protein deacetylases (sirtuins). A role for sirtuins in longevity determination was n the last decade, research into the molecular first suggested from work showing that deletion of SIR2 I determinants of aging has progressed rapidly and much shortens replicative life span [18], while overexpression of this progress can be attributed to studies in increases replicative life span [19]. Sir2 orthologs have since invertebrate eukaryotic model organisms. Of these, single- been reported to play a similar role in determining the celled yeast is the least complicated and most amenable to longevity of both worms and flies [20, 21]. genetic and molecular manipulations. Supporting the use of In yeast, both overexpression of SIR2 and deletion of FOB1 this organism for aging research, increasing evidence has repress homologous recombination at rDNA repeats. accumulated that a subset of pathways influencing longevity Recombination of rDNA results in the accumulation of in yeast are conserved in other eukaryotes, including extrachromosomal rDNA circles, which can lead to mammals. Here we briefly outline aging in yeast and describe replicative senescence [22]. While it was initially proposed recent findings that continue to keep this ‘‘simple’’ eukaryote that DR increases RLS in yeast by activating the Sir2 enzyme at the forefront of aging research. [11], this model has been