resting regulatory cd4 t cells a site of hiv persistence in patients on long-term effective antiretroviral therapy休息监管cd4 t细胞的艾滋病毒坚持长期有效的抗逆转录病毒治疗的病人.pdfVIP

Resting Regulatory CD4 T Cells: A Site of HIV Persistence in Patients on Long-Term Effective Antiretroviral Therapy 1 ¨ 1 2 1 Tu-Anh Tran , Marie-Ghislaine de Goer de Herve , Houria Hendel-Chavez , Bamory Dembele , Emilie Le ´ 2 2 4 ´ 1,3 1,3 Nevot , Karim Abbed , Coralie Pallier , Cecile Goujard , Jacques Gasnault , Jean-Franc¸ois 1,3 5 1,2 Delfraissy , Anne-Marie Balazuc , Yassine Taoufik * ´ ˆ ´ ˆ ˆ ˆ 1 INSERM U802, Universite Paris 11, Le Kremlin Bicetre, France, 2 Unite d’Immunologie Biologique, Assistance Publique-Hopitaux de Paris, Hopital Bicetre, Le Kremlin- ˆ ´ ˆ ˆ ˆ ˆ Bicetre, France, 3 Service de Medecine Interne, Assistance Publique-Hopitaux de Paris, Hopital Bicetre, Le Kremlin-Bicetre, France, 4 Laboratoire de Virologie, Assistance ˆ ˆ ˆ ˆ Publique-Hopitaux de Paris, Hopital Bicetre, Le Kremlin-Bicetre, France, 5 Institut Pasteur, Paris, France Abstract Background: In HIV-infected patients on long-term HAART, virus persistence in resting long-lived CD4 T cells is a major barrier to curing the infection. Cell quiescence, by favouring HIV latency, reduces the risk of recognition and cell destruction by cytotoxic lymphocytes. Several cell-activation-based approaches have