原创力文档risk stratification of latent tuberculosis defined by combined interferon gamma release assays潜伏性结核病的危险分层定义为联合干扰素释放试验.pdfVIP
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risk stratification of latent tuberculosis defined by combined interferon gamma release assays潜伏性结核病的危险分层定义为联合干扰素释放试验
Risk Stratification of Latent Tuberculosis Defined by
Combined Interferon Gamma Release Assays
´ ` 1 1 2 3 1
Veronique Corbiere , Gaelle Pottier , Florence Bonkain , Kinda Schepers , Virginie Verscheure ,
Sophie Lecher4,5,6,7, T. Mark Doherty8¤, Camille Locht4,5,6,7, Franc¸oise Mascart1,9*
´ ˆ ´
1 Laboratory of Vaccinology and Mucosal Immunity, Universite Libre de Bruxelles (U.L.B.) Brussels, Belgium, 2 Department of Nephrology, Hopital Erasme, Universite Libre
ˆ ´
de Bruxelles (U.L.B.) Brussels, Belgium, 3 Immunodeficiency Unit, Hopital Erasme, Universite Libre de Bruxelles (U.L.B.) Brussels, Belgium, 4 INSERM, U1019, Lille, France,
´
5 CNRS, UMR8204, Lille, France, 6 Universite de Lille Nord de France, Institut Pasteur de Lille, Lille, France, 7 Center for Infection and Immunity of Lille, Lille, France,
ˆ ´
8 Department of Tuberculosis Immunology, Statens Serum Institute, Copenhagen, Denmark, 9 Immunobiology Clinic, Hopital Erasme, Universite Libre de Bruxelles (U.L.B.),
Brussels, Belgium
Abstract
Background: Most individuals infected with Mycobacterium tuberculosis develop latent tuberculosis infection (LTBI). Some
may progress to active disease and would benefit from preventive treatment yet no means currently exists to predict who
will reactivate. Here, we provide an approach to strat
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