原创力文档rna binding protein cugbp2celf2 mediates curcumin-induced mitotic catastrophe of pancreatic cancer cellsrna结合蛋白cugbp2celf2介导curcumin-induced胰腺癌细胞的有丝分裂灾难.pdfVIP
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rna binding protein cugbp2celf2 mediates curcumin-induced mitotic catastrophe of pancreatic cancer cellsrna结合蛋白cugbp2celf2介导curcumin-induced胰腺癌细胞的有丝分裂灾难
RNA Binding Protein CUGBP2/CELF2 Mediates Curcumin-
Induced Mitotic Catastrophe of Pancreatic Cancer Cells
1 1 2 3
Dharmalingam Subramaniam *, Satish Ramalingam , David C. Linehan , Brian K. Dieckgraefe , Russell G.
4 5 6,7 1,5,7
Postier , Courtney W. Houchen , Roy A. Jensen , Shrikant Anant *
1 Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States of America, 2 Department of Surgery,
Washington University School of Medicine, St Louis, Missouri, United States of America, 3 Department of Medicine, Washington University School of Medicine, St Louis,
Missouri, United States of America, 4 Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America,
5 Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America, 6 Department of Pathology, University of
Kansas Medical Center, Kansas City, Kansas, United States of America, 7 The University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, Kansas,
United States of America
Abstract
Background: Curcumin inhibits the growth of pancreatic cancer tumor xenografts in nude mice; however, the mechanism
of action is not well understood. It is becoming increasingly clear that RNA binding proteins regulate posttranscriptional
gene expression and play a critical role in RNA stability and translation. Here, we have determined that curcumin modulates
the expression of RNA binding protein CUGBP2 to inhibit pancreatic cancer growth.
Methodology/Principal
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