原创力文档rlip76 regulates pi3kakt signaling and chemo-radiotherapy resistance in pancreatic cancerrlip76调节pi3kakt信号和在胰腺癌chemo-radiotherapy抵抗.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
rlip76 regulates pi3kakt signaling and chemo-radiotherapy resistance in pancreatic cancerrlip76调节pi3kakt信号和在胰腺癌chemo-radiotherapy抵抗
RLIP76 Regulates PI3K/Akt Signaling and Chemo-
Radiotherapy Resistance in Pancreatic Cancer
Kathryn Leake, Jyotsana Singhal, Lokesh Dalasanur Nagaprashantha, Sanjay Awasthi, Sharad S. Singhal*
Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope, Comprehensive Cancer Center, Duarte, California, United States of
America
Abstract
Purpose: Pancreatic cancer is an aggressive malignancy with characteristic metastatic course of disease and resistance to
conventional chemo-radiotherapy. RLIP76 is a multi-functional cell membrane protein that functions as a major mercapturic
acid pathway transporter as well as key regulator of receptor-ligand complexes. In this regard, we investigated the
significance of targeting RLIP76 on PI3K/Akt pathway and mechanisms regulating response to chemo-radiotherapy.
Research Design and Methods: Cell survival was assessed by MTT and colony forming assays. Cellular levels of proteins and
phosphorylation was determined by Western blot analyses. The impact on apoptosis was determined by TUNEL assay. The
anti-cancer effects of RLIP76 targeted interventions in vivo were determined using mice xenograft model of the pancreatic
cancer. The regulation of doxorubicin transport and radiation sensitivity were determined by transport studies and colony
forming assays, respectively.
Results: Our current studies reveal an encompassing model for the role of RLIP76 in regulating the levels of fundamental
proteins like PI3K, Akt, E-cadherin, CDK4, Bcl2 and PCNA which are of specific importance in the signal transduction from
critical upstream signaling cascades that determine the proliferation, apoptosis and differentiation of pancreatic cancer
cells. RLIP76 depletion also caused marked and sustained regression of established human BxPC-3 pancreatic cancer tumors
in nude mou
您可能关注的文档
- resting-state network disruption and apoe genotype in alzheimer's disease a lagged functional connectivity study静息状态的网络中断和载脂蛋白e基因型在阿尔茨海默病滞后功能连通性的研究.pdf
- restricted genetic diversity of hiv-1 subtype c envelope glycoprotein from perinatally infected zambian infants限制遗传多样性位围产期感染hiv - 1 c亚型包膜糖蛋白的赞比亚婴儿.pdf
- restricting dosage compensation complex binding to the x chromosomes by h2a.zhtz-1限制剂量补偿复杂绑定h2a.zhtz-1的x染色体.pdf
- restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma恢复p38皮质类固醇敏感的有丝分裂原激活蛋白激酶抑制外周血单核细胞从严重的哮喘.pdf
- result publication of chinese trials in world health organization primary registries世界卫生组织出版的中国试验结果主要注册.pdf
- responses of human endothelial cells to pathogenic and non-pathogenic leptospira species反应人类内皮细胞的致病性和非致病性钩端螺旋体的物种.pdf
- resurrection of a bull by cloning from organs frozen without cryoprotectant in a ？80°c freezer for a decade复活一头公牛的克隆器官没有冷冻保护剂在冻结 80°c冷冻了十年.pdf
- restriction of hiv-1 replication in monocytes is abolished by vpx of sivsmmpbj限制hiv - 1复制在单核细胞由vpx sivsmmpbj的废除.pdf
- results of antiretroviral treatment interruption and intensification in advanced multi-drug resistant hiv infection from the optima trial抗逆转录病毒治疗的中断和加强在先进耐多药hiv感染的最适条件试验.pdf
- rest-mediated regulation of extracellular matrix is crucial for neural developmentrest-mediated调节细胞外基质对神经发育是至关重要的.pdf
- rna interference mediated inhibition of dengue virus multiplication and entry in hepg2 cells登革病毒的rna干扰抑制介导的乘法和进入hepg2细胞.pdf
- rna interference of endochitinases in the sugarcane endophyte trichoderma virens 223 reduces its fitness as a biocontrol agent of pineapple diseaserna干扰的endochitinases甘蔗内生植物木霉属223年对降低其健身成生物药物的菠萝疾病.pdf
- rna interference is responsible for reduction of transgene expression after sleeping beauty transposase mediated somatic integrationrna干扰负责减少转基因表达的睡美人后转座酶介导体集成.pdf
- rna interference of four genes in adult bactrocera dorsalis by feeding their dsrnas四个基因的rna干扰在成人bactrocera背的喂养他们的极.pdf
- rna interference of trypanosoma brucei cathepsin b and l affects disease progression in a mouse modelrna干扰的锥虫属brucei组织蛋白酶b和l在小鼠模型中影响疾病进展.pdf
- rna interference of nadph-cytochrome p450 reductase results in reduced insecticide resistance in the bed bug, cimex lectulariusrna干扰nadph-cytochrome p450还原酶导致减少杀虫剂耐药性臭虫,温带臭虫.pdf
- rna modulators of complex phenotypes in mammalian cells在哺乳动物细胞rna调节器复杂的表型.pdf
- rna oxidation adducts 8-ohg and 8-oha change with aβ42 levels in late-stage alzheimer's diseaserna氧化加合物8-ohg aβ42水平8-oha变化和晚期老年痴呆症.pdf
- rna interference in schistosoma mansoni schistosomula selectivity, sensitivity and operation for larger-scale screeningrna干扰在曼氏裂体吸虫schistosomula选择性、灵敏度和操作大规模筛选.pdf
- rna polymerase promotes splicing, prevents degradationrna聚合酶促进拼接,防止退化.pdf
文档评论（0）