rna inhibition highlights cyclin d1 as a potential therapeutic target for mantle cell lymphomarna抑制了细胞周期蛋白d1作为一个潜在的治疗目标,套细胞淋巴瘤.pdfVIP

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rna inhibition highlights cyclin d1 as a potential therapeutic target for mantle cell lymphomarna抑制了细胞周期蛋白d1作为一个潜在的治疗目标,套细胞淋巴瘤.pdf

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rna inhibition highlights cyclin d1 as a potential therapeutic target for mantle cell lymphomarna抑制了细胞周期蛋白d1作为一个潜在的治疗目标,套细胞淋巴瘤

RNA Inhibition Highlights Cyclin D1 as a Potential Therapeutic Target for Mantle Cell Lymphoma 1,2 1,2 3 4 3 Shiri Weinstein , Rafi Emmanuel , Ashley M. Jacobi , Avigdor Abraham , Mark A. Behlke , 5 5 4 1,2 Andrew G. Sprague , Tatiana I. Novobrantseva , Arnon Nagler , Dan Peer * 1 Laboratory of NanoMedicine, Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel, 2 Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, Israel, 3 Integrated DNA Technologies, Inc., Coralville, Iowa, United States of America, 4 Division of Hematology, Chaim Sheba Medical Center, Tel Hashomer, Israel, 5 Alnylam Pharmaceuticals, Cambridge, Massachusetts, United States of America Abstract Mantle cell lymphoma is characterized by a genetic translocation results in aberrant overexpression of the CCND1 gene, which encodes cyclin D1. This protein functions as a regulator of the cell cycle progression, hence is considered to play an important role in the pathogenesis of the disease. In this study, we used RNA interference strategies to examine whether cyclin D1 might serve as a therapeutic target for mantle cell lymphoma. Knocking down cyclin D1 resulted in significant growth retardation, cell cycle arrest, and most importantly, induction of apoptosis. These results mark cyclin D1 as a target for mantle cell lymphoma and emphasize the therapeutic potential hidden in its silencing. Citation: Weinstein S, Emmanuel R, Jacobi AM, Abraham A, Behlke MA, et al. (2012) RNA Inhibition Highlights Cyclin D1 as a Potential Thera