rs4919510 in hsa-mir-608 is associated with outcome but not risk of colorectal cancerrs4919510 hsa - mir - 608与结果有关但不是结肠直肠癌的风险.pdfVIP

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rs4919510 in hsa-mir-608 is associated with outcome but not risk of colorectal cancerrs4919510 hsa - mir - 608与结果有关但不是结肠直肠癌的风险.pdf

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rs4919510 in hsa-mir-608 is associated with outcome but not risk of colorectal cancerrs4919510 hsa - mir - 608与结果有关但不是结肠直肠癌的风险

rs4919510 in hsa-mir-608 Is Associated with Outcome but Not Risk of Colorectal Cancer ´ 1. 1,2. 3 1 3 Brıd M. Ryan , Andrew C. McClary , Nicola Valeri , Dillon Robinson , Alessio Paone , 1 1 3 1 Elise D. Bowman , Ana I. Robles , Carlo Croce , Curtis C. Harris * 1 Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America, 2 Howard Hughes Medical Institute, National Cancer Institute, Bethesda, Maryland, United States of America, 3 Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America Abstract Background: Colorectal cancer is the third most incident cancer and cause of cancer-related death in the United States. MicroRNAs, a class of small non-coding RNAs, have been implicated in the pathogenesis and prognosis of colorectal cancer, although few studies have examined the relationship between germline mutation in the microRNAs with risk and prognosis. We therefore investigated the association between a SNP in hsa-mir-608, which lies within the 10q24 locus, and colorectal cancer. Methods and Results: A cohort consisting of 245 cases and 446 controls was genotyped for rs4919510. The frequency of the GG genotype was significantly higher in African Americans (15%) compared to Caucasians (3%) controls. There was no significant association between rs4919510 and colorectal cancer risk (African American: ORGG vs. CC 0.89 [95% CI, 0.41–1.80]) (Caucasian: ORGG vs. CC 1.76, ([95% CI, 0.48–6.39]). However, we did observe an association with survival. The GG genotype