原创力文档rs5888 variant of scarb1 gene is a possible susceptibility factor for age-related macular degenerationrs5888 scarb1基因的变异可能是年龄相关性黄斑变性的敏感性因素.pdfVIP
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rs5888 variant of scarb1 gene is a possible susceptibility factor for age-related macular degenerationrs5888 scarb1基因的变异可能是年龄相关性黄斑变性的敏感性因素
rs5888 Variant of SCARB1 Gene Is a Possible
Susceptibility Factor for Age-Related Macular
Degeneration
1,2 3 4 3 1,7
Jennyfer Zerbib , Johanna M. Seddon , Florence Richard , Robyn Reynolds , Nicolas Leveziel ,
5 6 ´ 2 2 ` 1 2
Pascale Benlian , Patrick Borel , Josue Feingold , Arnold Munnich , Gisele Soubrane , Josseline Kaplan ,
Jean-Michel Rozet2, Eric H. Souied 1,7*
1 Creteil University Eye Clinic, Faculte de Medecine Henri Mondor, Creteil, France, 2 Genetics Service, INSERM U781, Hopital Necker Enfants Malades, Paris, France, 3 Tufts
´
University school of Medicine and Ophthalmic of Epidemiology and Genetics Service, Tufts Medical Center, Boston, Massachusetts, United States of America, 4 Universite
Lille Nord de France, INSERM, UMR744, Institut Pasteur de Lille, Lille, France, 5 Universite Pierre et Marie Curie, Paris 6, Department of Molecular Biology and Biochemistry,
´ ´
Hopital Saint-Antoine, Paris, France, 6 INRA, UMR1260 « Nutriments Lipidiques et Prevention des Maladies Metaboliques », Marseille, France, 7 Unite Fonctionnelle de
Recherche Clinique, Creteil, France
Abstract
Major genetic factors for age-related macular degeneration (AMD) have recently been identified as susceptibility risk factors,
including variants in the CFH gene and the ARMS2 LOC387715/HTRA1locus . Our purpose
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