sedentary behaviour and biomarkers for cardiovascular disease and diabetes in mid-life the role of television-viewing and sitting at work久坐行为和心血管疾病和糖尿病的生物标志物在中年的角色通过电视观看和坐在工作.pdfVIP

Sedentary Behaviour and Biomarkers for Cardiovascular Disease and Diabetes in Mid-Life: The Role of Television- Viewing and Sitting at Work Snehal M. Pinto Pereira, Myung Ki, Chris Power* MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, United Kingdom Abstract Background: Knowledge of sedentary behaviour associations with health has relied mainly on television-viewing as a proxy and studies with other measures are less common. To clarify whether sedentary behaviour is associated with disease-risk, we examined associations for television-viewing and sitting at work. Methods: Using the 1958 British birth cohort (n = 7660), we analysed cross-sectional associations between television- viewing and work sitting (four categories, 0–1 to $3 h/d) with total, high-density lipoprotein (HDL) and low-density lipoprotein (LDL)-cholesterol, triglycerides, blood pressure, glycated haemoglobin, fibrinogen, C-reactive protein, hypertension and metabolic syndrome at 45 y. We adjusted for lifestyle and socio-demographic factors and assessed mediation of associations by body mass index (BMI) and diet. We also assessed whether the sedentary indicators are related similarly to factors linked to disease-risk. Results: There was a general trend of adverse socio-demographic and lifestyle characteristics with higher h/d television- viewing, but trends in the opposite direction for work sitting. Television-viewing was associated with most biomarkers and associations were mediated by BMI: e.g. for each category increase in television-viewing, HDL-cholesterol in men was lower by 2.3% (95% CI: 1.5%, 3.2%) and, in BMI and diet adjusted analyses, by 1.6% (0.8%, 2.4%); for women, by 2.0% (1.2%, 2.9%) and 0.9% (0.1%, 1.6%) respectively. Few, weaker associations for work sitting were