segmentation and visual analysis of whole-body mouse skeleton microspect分割和可视化分析,全身骨骼microspect老鼠.pdfVIP

Segmentation and Visual Analysis of Whole-Body Mouse Skeleton microSPECT 1 2 1 2,3 1,4 Artem Khmelinskii , Harald C. Groen , Martin Baiker , Marion de Jong , Boudewijn P. F. Lelieveldt * 1 Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands, 2 Department of Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands, 3 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands, 4 Department of Intelligent Systems, Delft University of Technology, Delft, The Netherlands Abstract Whole-body SPECT small animal imaging is used to study cancer, and plays an important role in the development of new drugs. Comparing and exploring whole-body datasets can be a difficult and time-consuming task due to the inherent heterogeneity of the data (high volume/throughput, multi-modality, postural and positioning variability). The goal of this study was to provide a method to align and compare side-by-side multiple whole-body skeleton SPECT datasets in a common reference, thus eliminating acquisition variability that exists between the subjects in cross-sectional and multi- modal studies. Six whole-body SPECT/CT datasets of BALB/c mice injected with bone targeting tracers 99mTc-methylene diphosphonate (99mTc-MDP) and 99mTc-hydroxymethane diphosphonate (99mTc-HDP) were used to evaluate the proposed method. An articulated version of the MOBY whole-body mouse atlas was used as a common reference. Its individual bones were registered one-by-one to the skeleton extracted from the acquired SPECT data following an anatomical hierarchical tree. Sequential registration was used while constraining the