screening for microsatellite instability identifies frequent 3′-untranslated region mutation of the rb1-inducible coiled-coil 1 gene in colon tumors筛选微卫星不稳定性识别频繁3u2032未翻译区突变的rb1-inducible卷曲螺旋1基因在结肠肿瘤.pdfVIP

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screening for microsatellite instability identifies frequent 3′-untranslated region mutation of the rb1-inducible coiled-coil 1 gene in colon tumors筛选微卫星不稳定性识别频繁3u2032未翻译区突变的rb1-inducible卷曲螺旋1基因在结肠肿瘤.pdf

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screening for microsatellite instability identifies frequent 3′-untranslated region mutation of the rb1-inducible coiled-coil 1 gene in colon tumors筛选微卫星不稳定性识别频繁3u2032未翻译区突变的rb1-inducible卷曲螺旋1基因在结肠肿瘤

Screening for Microsatellite Instability Identifies Frequent 39-Untranslated Region Mutation of the RB1- Inducible Coiled-Coil 1 Gene in Colon Tumors 1 1 3 4 1,2 Bogdan C. Paun , Yulan Cheng , Barbara A. Leggett , Joanne Young , Stephen J. Meltzer , Yuriko Mori1* 1 Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 2 Division of Gastroenterology, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 3 Conjoint Gastroenterology Lab, Royal Brisbane Hospital Foundation, Clinical Research Centre, Bancroft Centre, Herston, Queensland, Australia, 4 Familial Cancer Laboratory, Queensland Institute of Medical Research, Herston, Queensland, Australia Abstract Background: Coding region microsatellite instability (MSI) results in loss of gene products and promotion of microsatellite- unstable (MSI-H) carcinogenesis. Recent studies have indicated that MSI within 39-untranslated regions (39UTRs) may post- transcriptionally dysregulate gene products. Within this context, we conducted a broad mutational survey of 42 short 39UTR microsatellites (MSs) in 45 MSI-H colorectal tumors and their corresponding normal colonic mucosae. Methodology/Principal Findings: In order to estimate the overall susceptibility of MSs to MSI in MSI-H tumors, the observed MSI frequency of each MS was correlated with its length, interspecies sequence conservation level, and distance from some genetic elements (i.e., stop codon, polyA signal, and microRNA binding sites). All MSs were stable in normal colonic mucosae. The MSI frequency at each MS in M