routine laboratory results and thirty day and one-year mortality risk following hospitalization with acute decompensated heart failure常规的实验室结果和后30天,一年的死亡率与急性失代偿性心力衰竭住院治疗.pdfVIP

Routine Laboratory Results and Thirty Day and One-Year Mortality Risk Following Hospitalization with Acute Decompensated Heart Failure 1,2 2 3 1 1 1 Victor Novack *, Michael Pencina , Doron Zahger , Lior Fuchs , Roman Nevzorov , Allan Jotkowitz , Avi Porath1 1 Clinical Research Center, Soroka University Medical Center, Beer-Sheva, Israel, 2 Harvard Clinical Research Institute, Boston, Massachusetts, United States of America, 3 Cardiology, Soroka University Medical Center, Beer-Sheva, Israel Abstract Introduction: Several blood tests are performed uniformly in patients hospitalized with acute decompensated heart failure and are predictive of the outcomes: complete blood count, electrolytes, renal function, glucose, albumin and uric acid. We sought to evaluate the relationship between routine admission laboratory tests results, patient characteristics and 30-day and one-year mortality of patients admitted for decompensated heart failure and to construct a simple mortality prediction tool. Methods: A retrospective population based study. Data from seven tertiary hospitals on all admissions with a principal diagnosis of heart failure during the years 2002–2005 throughout Israel were captured. Results: 8,246 patients were included in the study cohort. Thirty day mortality rate was 8.5% (701 patients) and one-year mortality rate was 28.7% (2,365 patients). Addition of five routine laboratory tests results (albumin, sodium, blood urea, uric acid and WBC) to a set of clinical and demographic characteristics improved c-statistics from 0.76 to 0.81 for 30-days and from 0.72 to 0.76 for one-year mortality prediction (both p-values ,0.0001). Three dichotomized abnormal laboratory results with highest