sulforaphane inhibits prostaglandin e2 synthesis by suppressing microsomal prostaglandin e synthase 1萝卜硫素抑制前列腺素e2合成抑制微粒体前列腺素e合酶1.pdfVIP

Sulforaphane Inhibits Prostaglandin E2 Synthesis by Suppressing Microsomal Prostaglandin E Synthase 1 Jiping Zhou, Denise G. Joplin, Janet V. Cross, Dennis J. Templeton* Department of Pathology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America Abstract Sulforaphane (SFN) is a dietary cancer preventive with incompletely characterized mechanism(s) of cancer prevention. Since prostaglandin E2 (PGE2) promotes cancer progression, we hypothesized that SFN may block PGE2 synthesis in cancer cells. We found that SFN indeed block