原创力文档statistical methods in recent hiv noninferiority trials reanalysis of 11 trials统计方法在最近艾滋病毒非试验11再分析试验.pdfVIP
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statistical methods in recent hiv noninferiority trials reanalysis of 11 trials统计方法在最近艾滋病毒非试验11再分析试验
Statistical Methods in Recent HIV Noninferiority Trials:
Reanalysis of 11 Trials
Philippe Flandre*
´ ˆ `
INSERM UMR-S 943, University Pierre and Marie Curie (UPMC) Paris VI and Department of Virology, AP-HP, Pitie-Salpetriere Hospital, Paris, France
Abstract
Background: In recent years the ‘‘noninferiority’’ trial has emerged as the new standard design for HIV drug development
among antiretroviral patients often with a primary endpoint based on
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