利培酮片（Risperidone）.docVIP

利培酮片（Risperidone） Risperidone Tablets (Risperidone Tablets) (Wei Sitong) Ingredient: risperidone. Chemical name: 3 - [2 - [4 - (6 - fluorine - 1 - 2 - 3 -) - 1 - piperidine ethyl] - 6, 7, 8, 9 - four hydrogen 2 - methyl 4H pyridine [1, 2 - (-) pyrimidine - 4 - keto [traits] 1mg Risperidone Tablets is a white film, which is white after removing the coating 2mg Risperidone Tablets is a light orange film, which is white after removing the coating [pharmacology and toxicology] This product is a derivative of benzo, which is a new generation of antipsychotic drugs. The active ingredient, risperidone, is a selective monoamine antagonist with unique properties, which has a high affinity with the 5 - HT2 receptor of 5 HT and the D2 receptor of dopamine. Risperidone and also can (1 - adrenergic receptor binding, and affinity with the H1 histamine lower receptor and (2 adrenergic receptor binding. Risperidone does not bind to cholinergic receptors. Risperidone is a powerful D2 antagonist that can improve the positive symptoms of schizophrenia, but it induces less motor function and is more likely to suffer from tetanic syncope than classical antipsychotic drugs. A balance between the serotonin and dopamine antagonism in the central nervous system reduces the possibility of extrapyramidal side effects and extends the therapeutic effects to negative symptoms and emotional symptoms of schizophrenia (5). [pharmacokinetics] Risperidone can be absorbed completely after oral administration, and reaches the peak value of serum concentration within 1~2 hours, and the absorption is not influenced by food. In vivo, risperidone is partially metabolized to 9 risperidone, which has similar pharmacological effects as risperidone. The product can be rapidly distributed in vivo. The binding rate of plasma protein in risperidone is 88%, and the binding rate of plasma protein of 9 - risperidone is 77%. The elimination half-life of this medicine is about 3 hours, and the half-life of anti psycho