常见肿瘤标志物的意义（Significance of common tumor markers）.docVIP

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常见肿瘤标志物的意义（Significance of common tumor markers）.doc

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常见肿瘤标志物的意义（Significance of common tumor markers）

常见肿瘤标志物的意义（Significance of common tumor markers） Significance of common tumor markers Carcinoembryonic antigen (Carcinoembryonic, antigen, CEA) Originally thought that CEA is a specific marker of colorectal cancer and other malignant tumors subsequently found in endodermal layer cells can also be positive to the. Further studies have shown that blood levels of CEA increase in some benign and other non neoplastic diseases. Therefore, CEA is a broad-spectrum tumor marker. Clinical significance: (1) elevated serum CEA is mainly found in colon cancer, colorectal cancer, pancreatic cancer, gastric cancer, liver cancer, lung cancer, breast cancer, and other malignant tumors, with varying degrees of positive rate. (2) CEA continuous follow-up examination can be used to observe the curative effect and prognosis of malignant tumor after operation, and can also be used to observe the curative effect of the chemotherapy patients. Under normal circumstances, when the disease improves, the serum CEA concentration drops and the condition worsens. The total resection of the patient showed a decrease, but not normal. The patient who was unable to undergo resection and had undergone palliative surgery generally continued to rise. (3) intestinal diverticulum, rectal polyps, colitis, cirrhosis, hepatitis and lung diseases, CEA also increased in varying degrees, but the positive rate was low. (4) 98% of non smokers CEA5ug/L, about 3.9% of smokers have CEA5ug/L. (5) renal dysfunction can also rise slightly. Two, alpha fetoprotein (Alpha-fetoprotein, AFP) Fetal plasma AFP value can reach 3000ug/L, then decreased gradually after birth, the synthesis of AFP quickly suppressed, its content is reduced to 50ug/L, the age of the babys concentration close to the adult level, the general health of adult plasma AFP concentration is lower than 20ug/L. Clinical significance: (1) the serum concentration of AFP in patients with primary liver cancer was significantly higher, about 77.1% of patients ha