变温拉曼光谱和DSC探讨人参皂苷Rb1分.PDF

中国科技论文在线 变温拉曼光谱和DSC 探讨人参皂苷Rb1 分 子与DPPC 双层膜的作用# 1 1 2 1 2** 惠歌 ，刘威 ，周铁莉 ，赵雨 ，赵冰 5 （1. （（（（（（（（（（ 130117（ 2. （（（（（（（（（（（（（（（（（（（（ （（ 130012（ 摘要：采用变温拉曼光谱和差示扫描量热技术 （DSC ）探讨了人参皂苷Rb1 与DPPC 双层膜 的作用。结果表明，随着温度的增加，含有一定浓度Rb1 的DPPC 磷脂极性头部旁氏构象没 10 有发生变化，脂酰链的无序性构象增多，脂双层的流动性增加。DSC 实验进一步验证了变 温拉曼实验结果（说明Rb1 对DPPC 双层膜的影响较大（ 关键词：（（（（（DSC （（（（（ Rb1 （DPPC （（（ 中图分类号：064-3 15 Study on the Effect of Ginsenoside Rb1 on DPPC Bilayers by using Thermo-Raman Spectrum and DSC 1 1 2 1 2 Hui Ge , Liu Wei , Zhou Tieli , Zhao Yu , Zhao Bing (1. Changchun University of Traditional Chinese Medicine, Changchun 130117; 2. State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 20 130012) Abstract: In this paper, the influence of ginsenoside Rb1 on DPPC membrane bilayers was investigated by thermo – Raman and differential thermal scanning technology ( DSC ). Raman results showed that ginsenoside Rb1 molecule of certain concentration has not changed the gauche conformation of the polar head backbone group in DPPC bilayers, the order of the internal 25 molecular chain and the lateral chain-chain packing have been decreased as the temperature increased, and the fluidity of bilayers increased. The DSC showed further results of the thermo – Raman experiments, which indicated that the strong effects of ginsenoside Rb1 on DPPC. Key words: thermo – Raman; DSC; ginsenoside Rb1;