七星镇痛膏镇痛抗炎作用探究.docVIP

七星镇痛膏镇痛抗炎作用探究 　 作者：张信平， 李晓波， 周素文， 李旭升 【关键词】 七星镇痛膏；,,镇痛；,,抗炎 　　摘要：目的观察七星镇痛膏的镇痛抗炎作用。方法采用醋酸建立小鼠疼痛扭体模型及小鼠热板法，观察七星镇痛膏的镇痛作用；采用二甲苯所致小鼠耳廓肿胀和右旋糖酐所致大鼠足跖肿胀形成模型，观察七星镇痛膏的抗炎作用。结果七星镇痛膏剂量在0.4，0.2 g#12539;kg1对醋酸所致小鼠扭体次数的抑制率分别64.24%，24.24%；热板法证实七星镇痛膏在给药1 h后能明显提高小鼠的痛阈值（P＜0.05），痛阈值提高率为33.81%，16.67%；七星镇痛膏剂量在0.4，0.2 g#12539;kg1时，对二甲苯所致小鼠耳部炎症的抑制率分别为71.01%，70.04%；在给药后0.5~4 h对右旋糖酐所致大鼠足跖肿胀具有明显抑制作用（P＜0.01）。结论 七星镇痛膏对疼痛和炎症具有较显著的镇痛及抗炎作用。 　　关键词：七星镇痛膏； 镇痛； 抗炎 　　Abstract：ObjectiveTo research the abirritation and antiinflammatory effects of QiXingZhenTongGao.MethodsThe pain models induced by acetic acid and the hotplate tests in mice were used to observe the abirritation effect of QiXingZhenTongGao,the swellingauricles of mice caused by Xylol and swelling paws of rats induced by dextran were used to observe the antiinflammatory effects of QiXingZhenTongGao.ResultsThe inhibitory ratio of retortion of mice induced by acetic acid was 64.24% and 24.24% respectively after QiXingZhenTongGao being administered at the pain threshold of mice. The torlerant value increased remarkably after 1hour of QiXingZhenTongGao being administered verified by the hotplate tests(P＜0.05),with the increased ratio being 33.81% and 16.67% respectively at the dosage of 0.4 and 0.2 g/kg;the inhibition ratio of the mice auricle inflammation caused by xylol was 71.01%and 70.04%respectively at the dosage of QiXingZhenTongGao being administered 0.4 and 0.2 g/kg;the swelling paws of rats induced by dextran could be inhibited remarkably after QiXingZhenTongGao being administered 0.5~4 hours(P＜0.01).ConclusionQiXingZhenTongGao has a effect of abirritation and anti-inflammation. 　　Key words：QiXingZhenTongGao; Abirritation; Anti-inflammation 　　中医的痹证是临床常见病、多发病，类似于现代医学的自身免疫疾病的风湿病范畴，诸如类风湿性关节炎、风湿性关节炎、骨性关节炎、颈腰椎疼痛病症等。其临床症状主要表现有关节、肌肤、筋骨等部位疼痛，或肿胀、晨僵、麻木重着，或屈伸不利，甚至关节肿大变形、肌肉切缩等［1］。该病症中医药物治疗可分为内治和外治；内治主要口服汤剂等内服制剂，外治主要用中草药薰洗、外敷、针灸、按摩等，但无论内治或外治，其目的均为活血化淤、止痛抗炎等［2］。七星镇痛膏是根据祖传验方加减变化而来，主要由制川乌、制草乌、乳香等二十多味中草药经制剂加工制成，具有祛风散寒、活血化淤、通络止痛之功效。从临床应用几十年的结果观察来看，该