原创力文档a bayesian calibration model for combining different pre-processing methods in affymetrix chips结合不同的预处理方法的贝叶斯模型校准affymetrix芯片.pdfVIP
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a bayesian calibration model for combining different pre-processing methods in affymetrix chips结合不同的预处理方法的贝叶斯模型校准affymetrix芯片
BMC Bioinformatics BioMed Central
Methodology article Open Access
A Bayesian calibration model for combining different
pre-processing methods in Affymetrix chips
Marta Blangiardo* and Sylvia Richardson
Address: Centre for Biostatistics, Imperial College, St. Marys Campus, Norfolk Place, London, W2 1PG, UK
Email: Marta Blangiardo* - m.blangiardo@imperial.ac.uk; Sylvia Richardson - sylvia.richardson@imperial.ac.uk
* Corresponding author
Published: 1 December 2008 Received: 12 May 2008
Accepted: 1 December 2008
BMC Bioinformatics 2008, 9:512 doi:10.1186/1471-2105-9-512
This article is available from: /1471-2105/9/512
© 2008 Blangiardo and Richardson; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: In gene expression studies a key role is played by the so called pre-processing, a
series of steps designed to extract the signal and account for the sources of variability due to the
technology used rather than to biological differences between the RNA samples. At the moment
there is no commonly agreed gold standard pre-processing method and each researcher has the
responsibility to choose one method, incurring the risk of false positive and false negative features
arising from the particular method chosen.
Results: We propose a Bayesia
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