a direct comparison of protein interaction confidence assignment schemes直接比较的蛋白质交互分配计划的信心.pdfVIP

BMC Bioinformatics BioMed Central Research article Open Access A direct comparison of protein interaction confidence assignment schemes 1,2 3 3 3 Silpa Suthram , Tomer Shlomi , Eytan Ruppin , Roded Sharan and Trey Ideker* 1,2 Address: 1Department of Bioengineering, University of California, San Diego, CA 92093, USA, 2Program in Bioinformatics, University of California, San Diego, CA 92093, USA and 3School of Computer Science, Tel-Aviv University, Tel Aviv 69978, Israel Email: Silpa Suthram - ssuthram@; Tomer Shlomi - shlomito@post.tau.ac.il; Eytan Ruppin - ruppin@post.tau.ac.il; Roded Sharan - roded@post.tau.ac.il; Trey Ideker* - trey@ * Corresponding author Published: 26 July 2006 Received: 18 April 2006 Accepted: 26 July 2006 BMC Bioinformatics 2006, 7:360 doi:10.1186/1471-2105-7-360 This article is available from: /1471-2105/7/360 © 2006 Suthram et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Recent technological advances have enabled high-throughput measurements of protein-protein interactions in the cell, producing large protein interaction networks for various species at an ever-growing pace. However, common technol