手性羰基铁体系催化酮的不对称氢转移氢化.pdfVIP

2004 62 Vol. 62, 2004 18 , 1745~ 1750 ACTA CHIMICA SINICA No. 18, 1745~ 1750 陈建珊 陈玲玲 邢 雁 陈 贵 沈伟艺 董振荣 李岩云 高景星 ( 361005) . , . . , . [ Et NH] + [HF ( CO) ] - 1, 1 3 3 11 , 98% . , F ( CO) 3 12 . , , , Asymmetric Transfer Hydrogenation of Ketones Catalyzed by Chiral Carbonyl Iron Systems CHEN, JianShan CHEN, LingLing XING, Yan CHEN, Gui SHEN, W iYi DONG, Zh nRong LI, YanYun GAO, JingXing ( Department of Chemistry, State Key Laboratoryf or Physical Chemistry of Solid Surf aces, Xiamen University, Xiamen 36 005) Abstract Chiral carbonyl iron syst ms hav s ldom b n us d in asymm tric transf r hydrog nation of aromatic k ton s. In this study, n w chiral iron catalytic syst ms w r synth siz d in situ from diff r nt carbonyl iron compl x s with chiral diaminodiphosphin ligands, r sp ctiv ly. Th s catalytic syst ms hav b n us d for th asymm tric transf r hydrog nation of various aromatic k ton s und r mild conditions. Th r sults indicat d that trinucl ar iron compl x s w r th b st syst ms for th r actions. Wh n th [ Et NH] + [HF ( CO) ] - as catalyst 3 3 11 was us d for asymm tric r duction of 1, 1diph nylac ton , high nantios l ctivity up to 98% was achi v d. Monitoring th r action in situ by i