a prebiotic, celmanax?, decreases escherichia coli o157h7 colonization of bovine cells and feed-associated cytotoxicity in vitro生命起源以前的,celmanax ,减少大肠杆菌o157h7殖民的牛细胞和feed-associated体外细胞毒性.pdfVIP
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a prebiotic, celmanax?, decreases escherichia coli o157h7 colonization of bovine cells and feed-associated cytotoxicity in vitro生命起源以前的,celmanax ,减少大肠杆菌o157h7殖民的牛细胞和feed-associated体外细胞毒性
Baines et al. BMC Research Notes 2011, 4:110
/1756-0500/4/110
SHORT REPORT Open Access
A prebiotic, Celmanax™, decreases Escherichia
coli O157:H7 colonization of bovine cells and
feed-associated cytotoxicity in vitro
1* 1 1 2 3 4 5
Danica Baines , Stephanie Erb , Ross Lowe , Kelly Turkington , Emil Sabau , Gretchen Kuldau , Jean Juba ,
Luke Masson6, Alberto Mazza6 and Ray Roberts7
Abstract
Background: Escherichia coli O157:H7 is the most common serovar of enterohemorrhagic E. coli associated with
serious human disease outbreaks. Cattle are the main reservoir with E. coli O157:H7 inducing hemorrhagic enteritis
in persistent shedding beef cattle, however little is known about how this pathogen affects cattle health. Jejunal
Hemorrhage Syndrome (JHS) has unclear etiology but the pathology is similar to that described for E. coli O157:H7
challenged beef cattle suggestive that E. coli O157:H7 could be involved. There are no effective treatments for JHS
however new approaches to managing pathogen issues in livestock using prebiotics and probiotics are gaining
support. The first objective of the current study was to characterize pathogen colonization in hemorrhaged
jejunum of dairy cattle during natural JHS outbreaks. The second objective was to confirm the association of
mycotoxigenic fungi in feeds with the development of JHS and also to identify the presence of potential
mycotoxins. The third objective was to determine the impact of a prebiotic, Celmanax™, or probiotic, Dairyman’s
Choice™ paste, on the cytotoxicity associated with feed extracts in vitro. The fourth objective was to determine
the impact of a prebiotic or a probiotic on E. coli O157:H7 colonization of mucosal explants and a bovine
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