a proposed metric for assessing the measurement quality of individual microarrays提出了评估指标测量单个芯片的质量.pdfVIP

BMC Bioinformatics BioMed Central Research article Open Access A proposed metric for assessing the measurement quality of individual microarrays 1 1 1 2 Kyoungmi Kim , Grier P Page , T Mark Beasley , Stephen Barnes , 3 1 Katherine E Scheirer and David B Allison* Address: 1Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA, 2Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama, USA and 3Heflin Center for Human Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA Email: Kyoungmi Kim - kkim@; Grier P gpage@; T Mark Beasley - mbeasley@; Stephen Barnes - sbarnes@; Katherine E Scheirer - kscheire@; David B Allison* - dallison@ * Corresponding author Published: 23 January 2006 Received: 23 May 2005 Accepted: 23 January 2006 BMC Bioinformatics 2006, 7:35 doi:10.1186/1471-2105-7-35 This article is available from: /1471-2105/7/35 © 2006 Kim et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: High-density microarray technology is increasingly applied to study gene expression levels on