a simple and robust method for connecting small-molecule drugs using gene-expression signatures一个简单的和健壮的方法连接小分子药物使用基因表达特征.pdfVIP

BMC Bioinformatics BioMed Central Methodology article Open Access A simple and robust method for connecting small-molecule drugs using gene-expression signatures Shu-Dong Zhang* and Timothy W Gant* Address: MRC Toxicology Unit, Hodgkin Building, Lancaster Road, University of Leicester, Leicester, UK Email: Shu-Dong Zhang* - sdz1@le.ac.uk; Timothy W Gant* - twg1@le.ac.uk * Corresponding authors Published: 2 June 2008 Received: 15 February 2008 Accepted: 2 June 2008 BMC Bioinformatics 2008, 9:258 doi:10.1186/1471-2105-9-258 This article is available from: /1471-2105/9/258 © 2008 Zhang and Gant; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Interaction of a drug or chemical with a biological system can result in a gene- expression profile or signature characteristic of the event. Using a suitably robust algorithm these signatures can potentially be used to connect molecules with similar pharmacological or toxicological properties by gene expression profile. Lamb et al first proposed the Connectivity Map [Lamb et al (2006), Science 313, 1929–1935] to make successful connections among small molecules, genes, and diseases using genomic signatures. Results: Here we have