原创力文档a simple dependence between protein evolution rate and the number of protein-protein interactions之间的一个简单的依赖蛋白质进化率和蛋白质相互作用的数量.pdfVIP
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a simple dependence between protein evolution rate and the number of protein-protein interactions之间的一个简单的依赖蛋白质进化率和蛋白质相互作用的数量
BMC Evolutionary Biology BioMed Central
Research article Open Access
A simple dependence between protein evolution rate and the
number of protein-protein interactions
1 2 2
Hunter B Fraser* , Dennis P Wall and Aaron E Hirsh
Address: 1Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA and 2Center for Computational Genetics
and Biological Modeling, Department of Biological Sciences, Stanford University, Stanford, CA, 94305, USA
Email: Hunter B Fraser* - hunter@; Dennis P Wall - dpwall@; Aaron E Hirsh - aehirsh@
* Corresponding author
Published: 23 May 2003 Received: 27 March 2003
Accepted: 23 May 2003
BMC Evolutionary Biology 2003, 3:11
This article is available from: /1471-2148/3/11
© 2003 Fraser et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all
media for any purpose, provided this notice is preserved along with the articles original URL.
Abstract
Background: It has been shown for an evolutionarily distant genomic comparison that the
number of protein-protein interactions a protein has correlates negatively with their rates of
evolution. However, the generality of this observation has recently been challenged. Here we
examine the problem using protein-protein interaction data from the yeast Saccharomyces cerevisiae
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