原创力文档a systematic design method for robust synthetic biology to satisfy design specifications坚实的合成生物学的系统设计方法,以满足设计规范.pdfVIP
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a systematic design method for robust synthetic biology to satisfy design specifications坚实的合成生物学的系统设计方法,以满足设计规范
BMC Systems Biology BioMed Central
Research article Open Access
A systematic design method for robust synthetic biology to satisfy
design specifications
Bor-Sen Chen* and Chih-Hung Wu
Address: Lab of Systems Biology, Department of Electrical Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan
Email: Bor-Sen Chen* - bschen@.tw; Chih-Hung Wu - g883743@.tw
* Corresponding author
Published: 30 June 2009 Received: 2 December 2008
Accepted: 30 June 2009
BMC Systems Biology 2009, 3:66 doi:10.1186/1752-0509-3-66
This article is available from: /1752-0509/3/66
© 2009 Chen and Wu; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Synthetic biology is foreseen to have important applications in biotechnology and
medicine, and is expected to contribute significantly to a better understanding of the functioning of
complex biological systems. However, the development of synthetic gene networks is still difficult
and most newly created gene networks are non-functioning due to intrinsic parameter
uncertainties, external disturbances and functional variations of intra- and extra-cellular
environments. The design method for a robust synthetic gene network that works properly in a
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