a systematic approach to detecting transcription factors in response to environmental stresses一套系统的方法来检测转录因子对环境压力的反应.pdfVIP

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a systematic approach to detecting transcription factors in response to environmental stresses一套系统的方法来检测转录因子对环境压力的反应.pdf

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a systematic approach to detecting transcription factors in response to environmental stresses一套系统的方法来检测转录因子对环境压力的反应

BMC Bioinformatics BioMed Central Methodology article Open Access A systematic approach to detecting transcription factors in response to environmental stresses Li-Hsieh Lin†1, Hsiao-Ching Lee†2, Wen-Hsiung Li3,4 and Bor-Sen Chen*1 Address: 1Lab of Systems Biology, Department of Electronical Engineering, National Tsing Hua University, 101, Sec 2, Kuang Fu Hsinchu, 300, Taiwan, 2Department of Life Science Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, 300, Taiwan, 3Department of Ecology and Evolution, University of Chicago, USA and 4Genomics Research Center, Academia Sinica, Taipei, Taiwan Email: Li-Hsieh Lin - LHlin@.tw; Hsiao-Ching Lee - d884234@.tw; Wen-Hsiung Li - whli@; Bor- Sen Chen* - bschen@.tw * Corresponding author †Equal contributors Published: 8 December 2007 Received: 9 June 2007 Accepted: 8 December 2007 BMC Bioinformatics 2007, 8:473 doi:10.1186/1471-2105-8-473 This article is available from: /1471-2105/8/473 © 2007 Lin et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Eukaryotic cells have developed mechanisms to respond to external environmental or physiological changes (stresses). In order to increase the activities of stress-protection functions in response to an environmental change, the int