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activation of toll-like receptors by burkholderia pseudomalleitoll样受体的激活伯克举办
BMC Immunology BioMed Central
Research article Open Access
Activation of Toll-like receptors by Burkholderia pseudomallei
T Eoin West*, Robert K Ernst, Malinka J Jansson-Hutson and Shawn J Skerrett
Address: Department of Medicine, University of Washington, Seattle, Washington, USA
Email: T Eoin West* - tewest@; Robert K Ernst - rkernst@; Malinka J Jansson-
Hutson - mjj2@; Shawn J Skerrett - shawn@
* Corresponding author
Published: 8 August 2008 Received: 16 April 2008
Accepted: 8 August 2008
BMC Immunology 2008, 9:46 doi:10.1186/1471-2172-9-46
This article is available from: /1471-2172/9/46
© 2008 West et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Melioidosis, a lethal tropical infection that is endemic in southeast Asia and northern
Australia, is caused by the saprophytic Gram-negative bacterium Burkholderia pseudomallei. Overall
mortality approaches 40% yet little is known about mechanisms of host defense. Toll-like receptors
(TLRs) are host transmembrane receptors that recognize conserved pathogen molecular patterns
and induce an inflammatory response. The lipopolysaccharide (LPS) of Gram-negative bacteria is a
potent inducer of the host innate immune system. TLR4, in association with MD-2, is the archetype
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