adjuvant breast cancer chemotherapy during late-trimester pregnancy not quite a standard of care乳腺癌辅助化疗期间late-trimester怀孕不是一个标准的护理.pdfVIP
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adjuvant breast cancer chemotherapy during late-trimester pregnancy not quite a standard of care乳腺癌辅助化疗期间late-trimester怀孕不是一个标准的护理
BMC Cancer BioMed Central
Debate Open Access
Adjuvant breast cancer chemotherapy during late-trimester
pregnancy: not quite a standard of care
Richard J Epstein*
Address: Division of Haematology/Oncology, Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
Email: Richard J Epstein* - repstein@hku.hk
* Corresponding author
Published: 30 May 2007 Received: 28 September 2006
Accepted: 30 May 2007
BMC Cancer 2007, 7:92 doi:10.1186/1471-2407-7-92
This article is available from: /1471-2407/7/92
© 2007 Epstein; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Diagnosis of breast cancer during pregnancy was formerly considered an indication
for abortion. The pendulum has since swung to the other extreme, with most reviews now
rejecting termination while endorsing immediate anthracycline-based therapy for any pregnant
patient beyond the first trimester. To assess the evidence for this radical change in thinking, a
review of relevant studies in the fields of breast cancer chemotherapy, pregnancy, and drug safety
was conducted.
Discussion: Accumulating evidence for the short-term safety of anth
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