accumulation of marginal zone b cells and accelerated loss of follicular dendritic cells in nf-κb p50-deficient mice边缘区b细胞积累和加速滤泡树突细胞的损失nf-κb p50-deficient老鼠.pdfVIP

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accumulation of marginal zone b cells and accelerated loss of follicular dendritic cells in nf-κb p50-deficient mice边缘区b细胞积累和加速滤泡树突细胞的损失nf-κb p50-deficient老鼠.pdf

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accumulation of marginal zone b cells and accelerated loss of follicular dendritic cells in nf-κb p50-deficient mice边缘区b细胞积累和加速滤泡树突细胞的损失nf-κb p50-deficient老鼠

BMC Immunology BioMed Central Research article Open Access Accumulation of marginal zone B cells and accelerated loss of follicular dendritic cells in NF-κB p50-deficient mice Andrew R Ferguson and Ronald B Corley* Address: Department of Microbiology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118 USA Email: Andrew R Ferguson - arf@; Ronald B Corley* - rbcorley@ * Corresponding author Published: 18 April 2005 Received: 18 November 2004 Accepted: 18 April 2005 BMC Immunology 2005, 6:8 doi:10.1186/1471-2172-6-8 This article is available from: /1471-2172/6/8 © 2005 Ferguson and Corley; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Marginal zone (MZ) B cells play important roles in the early phases of humoral immune responses. In addition to possessing an inherent capacity to rapidly differentiate into antibody secreting cells, MZ B cells also help to regulate the fate of both T-independent and T- dependent blood-borne antigens in the spleen. For T-dependent antigens, MZ B cells bind IgM- antigen complexes in a complement-dependent manner. Once MZ B cells bind IgM-containing immune complexes (IgM-IC), they transport them into B cell follicles for deposition o