原创力文档a systems biology framework for modeling metabolic enzyme inhibition of mycobacterium tuberculosis系统生物学建模框架代谢酶抑制结核分枝杆菌.pdfVIP
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a systems biology framework for modeling metabolic enzyme inhibition of mycobacterium tuberculosis系统生物学建模框架代谢酶抑制结核分枝杆菌
BMC Systems Biology BioMed Central
Research article Open Access
A systems biology framework for modeling metabolic enzyme
inhibition of Mycobacterium tuberculosis
Xin Fang, Anders Wallqvist and Jaques Reifman*
Address: Biotechnology HPC Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical
Research and Materiel Command, Ft. Detrick, MD 21702, USA
Email: Xin Fang - xfang@; Anders Wallqvist - awallqvist@; Jaques Reifman* - jaques.reifman@
* Corresponding author
Published: 15 September 2009 Received: 5 April 2009
Accepted: 15 September 2009
BMC Systems Biology 2009, 3:92 doi:10.1186/1752-0509-3-92
This article is available from: /1752-0509/3/92
© 2009 Fang et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Because metabolism is fundamental in sustaining microbial life, drugs that target
pathogen-specific metabolic enzymes and pathways can be very effective. In particular, the
metabolic challenges faced by intracellular pathogens, such as Mycobacterium tuberculosis, residing in
the infected host provide novel opportunities for therapeutic intervention.
Results: We developed a mathematical framework to simulate the effects on the growth of a
pathogen when enzymes in it
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